Sunday 29 September 2013

Can Oral Sex Cause Throat Cancer?

Michael Douglas was diagnosed with throat cancer (oropharyngeal cancer) three years ago. He initially said it was caused by years of heavy smoking, alcohol abuse and stress. However, he recently told The Guardian newspaper that it was caused by oral sex (cunnilingus).

In an Interview with Guardian reporter, Xan Brooks, Douglas said that his type of cancer was caused by the human papillomavirus (HPV) "which actually comes from cunnilingus". His agent later said Douglas had been talking generally, and not about his own cancer, but the Guardian responded by publishing the sound recording of the interview that clearly showed he blamed oral sex for his cancer, and not years of drinking, smoking and stress.

Douglas first revealed details of his throat cancer in the David Letterman Show, in September 2010.

So, what is the risk of developing throat cancer from oral sex?

Gypsyamber D'Souza, PhD, MPH, from the Johns Hopkins School of Public Health, and team explained at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago, Illinois, that throat cancers that arise from HPV do not appear to raise the risk for domestic partners of the same cancer.

Dr. D'Souza explained that in their pilot study, they found that the prevalence of HPV among partners/spouses of an affected patient was approximately 7%, no different from that of the general population.

The team found that the HPV 16 subtype was present in just 2% of female partners and 0% of male partners. HPV 16 is responsible for the majority of throat cancers. Of the partners/spouses who underwent a visual oral exam, none had cancer or pre-cancer.

D'Souza explained that the risk of developing head and neck cancers for people whose partners have HPV-related cancer is very low.

At a press briefing, D'Souza said "Many people become infected but are able to clear those infections."

The researchers added that partners who have been together for a long time probably already share whatever infections they have. No changes in physical intimacy are needed, they emphasized. Put more simply "Couples will infect each other with whatever they have anyway - oral sex will neither increase nor reduce infection risk".

Oral sex with 6 or more partners raises risk of throat cancer, said one study

In a study published in NEJM (New England Journal of Medicine), Dr Maura Gillison of Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland, USA, and team suggested that people who have oral sex with at least 6 different partners have a significantly higherrisk of developing, throat cancer.

The team recruited 100 patients who had recently been diagnosed with oropharyngeal cancer, as well as 200 "healthy" individuals (the control group).

They found that people who had at least 6 oral-sex partners during their lifetime were 3.4 times more likely to have throat cancer. Those with 26 or more vaginal-sex partners had a 3.1 times higher risk of developing throat cancer.

What are the risk factors for throat cancer?

Smoking - this is by far the most important risk factor for throat cancer. Regular, long-term, heavy smokers are 20 times more likely to develop some type of throat cancer compared to non-smokers.

Alcohol - heavy, chronic alcohol consumption, particularly spirits, also raises the risk of developing throat cancer.

People who do both - drink and smoke a lot - have the highest risk.

Frequent heartburn - non-drinkers and non-smokers who have frequent heartburn have a higher risk of developing cancers of the throat and vocal cord.

Written by Christian Nordqvist

Bee Venom Destroys HIV And Spares Surrounding Cells

Nanoparticles containing bee venom toxin melittin can destroy human immunodeficiency virus (HIV) while at the same time leaving surrounding cells unharmed, scientists from Washington University School of Medicine reported in the March 2013 issue of Antiviral Therapy.

The researchers said that their finding is a major step toward creating a vaginal gel that can prevent HIV spread. HIV is the virus that causes AIDS.

Joshua L. Hood, MD, PhD, a research instructor in medicine, said: 

"Our hope is that in places where HIV is running rampant, people could use this gel as a preventive measure to stop the initial infection."

Melittin destroys some viruses and malignant tumor cells

Melittin is a powerful toxin found in bee venom. It can poke holes in the protective viral envelope that surrounds the human immunodeficiency virus, as well as other viruses. Free melittin in large-enough quantities can cause considerable damage.

Senior author, Samuel A. Wickline, MD, the J. Russell Hornsby Professor of Biomedical Sciences, has demonstrated that nanoparticles loaded with melittin have anti-cancer properties and have the capacity to kill tumor cells. Linking bee venom with anticancer therapies is not new, in 2004 Croatian scientists reported in the Journal of the Science of Food and Agriculture that honey-bee products, including venom, could well have applications in cancer treatment and prevention.

Normal cells remain intact - the scientists showed that nanoparticles loaded with melittin do not harm normal, healthy cells. Protective bumpers were added to the nanoparticles surface, so that when they come into contact with normal cells (which tend to be much larger), the nanoparticles bounce off rather than attach themselves.

Scientists have discovered a powerful toxin in bee venom that could end up playing a crucial role on preventing the spread of HIV.

HIV is much smaller than the nanoparticles and fits in between the bumpers. When HIV comes across a nanoparticle it goes in between the bumpers and comes into direct contact with its surface, which is coated with the bee toxin, which destroys it.

Hood explained "Melittin on the nanoparticles fuses with the viral envelope. The melittin forms little pore-like attack complexes and ruptures the envelope, stripping it off the virus."

While most anti-HIV medications work on inhibiting the virus' ability to replicate, this one attacks a vital part of its structure. The problem with attacking a pathogen's ability to replicate is that it does not stop it from starting an infection. Some HIV strains have found ways to circumvent replication-inhibiting drugs, and reproduce regardless.

Hood said, "We are attacking an inherent physical property of HIV. Theoretically, there isn't any way for the virus to adapt to that. The virus has to have a protective coat, a double-layered membrane that covers the virus."

Melittin nanoparticles may prevent and treat existing HIV infections

Hood believes that the melittin-loaded nanoparticles have the potential for two types of therapies:
  • A vaginal gel to prevent the spread of HIV infection
  • Therapy for existing HIV infections, particularly drug-resistant ones
In theory, if the nanoparticles were injected into the patient's bloodstream, they should be able to clear the blood of HIV.

Hood said "The basic particle that we are using in these experiments was developed many years ago as an artificial blood product. It didn't work very well for delivering oxygen, but it circulates safely in the body and gives us a nice platform that we can adapt to fight different kinds of infections."

Melittin attacks double-layered membranes indiscriminately, making it a potential for drug therapies beyond HIV infections. The hepatitis B and C viruses, among several others, rely on the same type of protective envelope and could be targeted and destroyed by administering melittin-loaded nanoparticles.

The gel also has the potential to target sperm, the researchers explained, making it a possible contraceptive medication. The study, however, did not look at contraception.

Hood said "We also are looking at this for couples where only one of the partners has HIV, and they want to have a baby. These particles by themselves are actually very safe for sperm, for the same reason they are safe for vaginal cells."

This study was carried out in cells in a laboratory environment. However, the nanoparticles are easy to produce - enough of them could easily be supplied for future human studies.

Recent research on HIV

Over the last few years, scientists have made strides in improving HIV/AIDS treatments and prevention strategies.

Baby "functionally cured" of HIV infection - researchers from Johns Hopkins Children's Center, the University of Mississippi Medical Center and the University of Massachusetts Medical School reported that a baby who was administered antiretroviral therapy thirty hours after being born was "functionally cured". A functional cure means that there is no detectable viral replication after retroviral therapy has stopped.

Ramping up HIV antiretroviral treatments worth the extra cost - investigators from Harvard University, USA, reported that scaling up HIV antiretroviral treatment in a remote province of South Africa (KwaZulu-Natal) reduced the risk of transmitting HIV to sexual partners by 96%.

Written by Christian Nordqvist

What Are Fordyce Spots? What Causes Fordyce Spots?

Fordyce spots, also known as Fordyce's spots, Fordyce granules or Sebaceous Prominence, are small raised, pale red, yellow-white or skin-colored bumps or spots that appear on the shaft of the penis, the labia, scrotum, or the vermilion border of the lips of a person's face. They can also be found on the foreskin of the penis (called Tyson's glands).

The vermilion (vermillion) border of the lips is the normally sharp demarcation between the red colored part of the lip and the adjacent normal skin of the face.

Fordyce Spots are named after the American dermatologist John Addison Fordyce (1858-1925) who first described them clinically in a medical journal. He also coined the terms Fox Fordyce disease, Fordyce's disease, Fordyce's lesion, and Brooke-Fordyce trichoepithelioma.

Fordyce Spots are common in both males and females.

Fordyce spots are a type of ectopic sebaceous gland:
  • Ectopic = in an abnormal location or position.
  • Sebaceous - fatty, greasy, adipose, fat - relating to oil and fat
  • Glands = organs or collection of cells that secrete things. Endocrine glands secrete things, such as hormones, into the body. Exocrine glands secrete things outside the body, such as sweat or mucus.
  • Sebaceous gland = a small skin gland that secretes sebum (oily matter) into the hair follicles to lubricate the hair and skin
  • Ectopic sebaceous gland = a sebaceous gland that is on the skin but not in the hair follicle.
According to Medilexicon's medical dictionary, Fordyce spots are:
"A condition marked by the presence of numerous small, yellowish-white bodies or granules on the inner surface and vermilion border of the lips; histologically the lesions are ectopic sebaceous glands."

Although Fordyce Spots are sebaceous glands which are in "the wrong place" (not in hair follicles), they are not associated with any disease or illness. Dermatologists say they are of cosmetic concern only - people who have them might not be happy with how they affect the way they look.

Experts say that Fordyce Spots are natural occurrences on the body and are not infectious. Some men may wonder whether they have some kind of STI (sexually transmitted infection) or cancer and see their doctor, only to be told that they are harmless.

What are the signs and symptoms of Fordyce Spots?

Small, pale (skin color, yellowish or pinkish) bumps or spots from 1 to 3 mm in diameter are visible on the:
  • Shaft of the penis (in males)
  • Scrotum (in males)
  • Where the lips on the face meet the skin of the face (vermilion border)
  • Labia (in females)
On the penis glans/shaft, scrotum and labia they may appear as bright red or purple papules, as a solitary lesion or in crops of 50 to 100. They are painless and do not itch. They are simply abnormally dilated blood vessels that are covered by thickened skin. In some cases they made bleed during/after intercourse.

fordycespots
30-year-old male patient, worried about herpes simplex, saw his doctor. Physical examination revealed several 1mm-wide smooth, white spots. He was diagnosed with Fordyce Spots (Hong Kong Medical Association)

What are the treatment options for Fordyce Spots?

Dermatologists and primary care physicians (general practitioners, family doctors) emphasize that Fordyce Spots are normal physiological occurrences and are not dangerous for human health. Many, in fact, advise against treatment.

Electro desiccation or CO2 laser have been used with some degree of success in making the spots less visible, if the patient's concern is purely cosmetic.

Pulsed dye lasers have also been anecdotally reported to be effective in some cases. This is a laser treatment usually used for sebaceous gland hyperplasia (a skin disorder of the sebaceous glands, basically, an enlarged oil gland). Although expensive, pulsed dye lasers tend to leave fewer scars than other methods.

In the majority of cases, the treatment methods mentioned above are not effective enough for most patients. However, a recent article regarding a Micro-punch technique provides some hope.

Micro-punch technique for treatment of Fordyce spots - Professor Norbert Pallua, who works at the Department of Plastic Surgery, Hand Surgery, Burn Center, University Hospital RWTH Aachen, Germany, reported in the Journal of Plastic, Reconstructive & Aesthetic Surgery promising results with Micro-punch technique for the treatment of Fordyce spots.

In a retrospective study involving 23 patients from 2003 to 2011, Pallua and team say they achieved satisfactory functional and cosmetic results. They added that so far during post-operative observations, there have been no signs of recurrence from 12 up to 84 months (median = 51.3 months).

What are the possible complications of Fordyce Spots?

For patients with severe Fordyce Spots on the vermilion border of the lips of the face, there is a risk of anxiety and depression, because the eyes and lips are the first things people look at. The spots can affect people emotionally.

Those with severe symptoms in their genitalia may be embarrassed or concerned about what their sexual partners might think. In some cases, the spots may bleed if injured or during intercourse.

Many doctors fail to diagnose Fordyce Spots accurately

It is not uncommon for patients with Fordyce Spots on their lips to go to several dermatologists and plastic surgeons and find that only a minority are able to identify what they are and to provide information regarding their causes, nature and possible treatments.

Written by Christian Nordqvist

The Trouble With Sleep Texting

The premed student sleeps with mittens on each night.

Mittens, to protect herself from her phone. To render her fingers unable to send those unconscious messages that are as embarrassing as they are senseless.
Yup: She's a sleep texter.

"It's a phenomenon occurring with the younger generation," says Elizabeth Dowdell, a nursing professor at Villanova University who shared the anecdote about the mitten-wearing student. "And it's reflective of the significance of our smartphones – of these very powerful machines. Why would we turn them off?"

Indeed, young adults are so attached to their phones that many respond to texts while they're sleeping. When the phone beeps they answer, either in words or, often, gibberish. And the next morning, they have no memory of their activity – until they check their message history. Sleep texters commonly recount their behavior using hashtags like #sleeptexting on Twitter and Instagram.

Dowdell initially learned about sleep texting when one of her students described her nighttime activities. After growing more intrigued, she surveyed 300 students, and learned that 25 to 35 percent had sent text messages while they were snoozing. And more than 50 percent admitted that their phone or other technology interfered with their sleep in some way.

That's what's worrisome, experts say. Sleep texting tends to occur during naps or about 90 minutes to two hours into the snoozing process, prior to entering a deep sleep. "Sleep is a very important restorative process," says Josh Werber, a snoring specialist at EOS Sleep Centers in Long Island, N.Y. "And when we're not fully engaged in it, and not getting the amount we need, we're not having the same restorative effect on our brains. And that affects our cognitive ability the next day."

Indeed, experts estimate we need between 7 and 8 hours of sleep each night. When we don't get enough, we're more likely to experience trouble succeeding at school and work. Sleep deprivation also hikes the odds of obesity, high blood pressure, depression, behavioral problems and drug abuse. And research suggests that sleep problems during adolescence don't simply disappear with age – they can continue to affect health long into adulthood.

Still, it's perhaps unsurprising that we remain attached to our smartphones even during sleep. Many of us are glued to these devices all day, every day – triggering new buzzwords like "cell phone dependence." Research from the Pew Internet & American Life Project suggests that teens spend about an hour and a half texting each day, and 1 in 3 sends more than 100 text messages a day. At least 4 in 5 teens sleep with their phone on or near the bed, seemingly inviting sleep texting.

For the most part, it's harmless, Dowdell says – aside from the long-term effect on our sleep health. Most often, these texts are innocent in nature; those sent by young men, for example, often revolve around food: "I'm starving. Let's get a pizza! Let's go work out." One young woman Dowdell studied, however, had a tendency to wax romantic when she texted as she slept. "A classmate texted her something about anatomy class, and her reply back was, 'I just love it. I love you! You're the light of my life,'" Dowdell recalls. "Then there was an old boyfriend who texted her, and she sent responses like, 'I adore you, please come over,' while she was asleep. She was mortified when she realized."

The romantic texter now makes sure her iPhone is out of reach when she snoozes. And that's exactly the kind of adaptive behavior that's necessary, experts say. If you're worried about texting while you're snoozing, take steps to establish the bedroom as a sanctuary. "It shouldn't be a workplace," Werber says. "It shouldn't be a place where we're multitasking. We feel strongly that people need to prepare for sleep, and now that these devices are so small and transportable, they're easy to bring into the bedroom. But that's unfortunately creating an issue in terms of sleep habits."

Try setting your phone out of reach when you go to bed, whether it's at your feet or on top of your dresser. Turn it off, or at least silence it. Set boundaries for yourself: Schedule a time to step away from your electronics each night, and realize that you don't have to reply instantaneously. It's OK to disconnect.

"It's learning to turn it off," Dowdell says. "Technology is very seductive. At the end of the day, you need to give yourself permission to really get your sleep. Maybe we don't need to be connected 24-7 – maybe it's better to be connected 18-7."

And if all else fails? We hear mittens come in plenty of cute designs these days.

Friday 13 September 2013

KISS ME MAYBE

Tongue-tied? These proven pointers on becoming a smooth kisser should help.

A man's kiss is his signature. When Mae West, one of Hollywood's wittiest sex goddesses, says that, you better ensure your autograph is up to the mark. As it turns out, there's really no solid set of instructions to follow if you want to blow a woman's mind with a kiss. Here are some proven ways - courtesy research or science - to turn you into a great kisser. 


ENTER HER SPACE

What perhaps sets off most jitters, than anything else, is not knowing whether she wants to kiss you. Merely assessing this possibility is enough to reduce you into a bundle of nerves. The solution lies in breaking into her personal space in the most non-intimidating manner and observing her reaction. 

To be as near her as being able to smell her hair, you must have some basic level of trust or expectation. If she looks into your eyes, or gives you a friendly smile or kiss, it may be her unspoken hint at liking you. 

The simplest way to find this out is to adjust her hair. Since it's an intimate gesture, she will either flinch - which means stay away - or respond with a smile, which could indicate she's interested. The best part though is that neither will have to feel awkward post this move. 

EVERY BREATH YOU TAKE

Poor oral hygiene is the perfect non-starter you should be wary of. Even if she is hot for you, it can ruin the moment before it begins. Women rely on smell and taste to a great extent, and also subconsciously make a note of teeth while evaluating a partner. 

A man's style of kissing also gives women a fair idea of his potential as a lover or whether to start a long-term relationship. In studies, women have rated the breath and taste of a man's kiss as critical in figuring whether to kiss him again. Women also value the pleasure of kissing far more than men do, whether it is before, during or after a sexual encounter. 

RHYTHM AND TEMPO

Get a hang of her breathing rate and help her breathe easily when you kiss. Women are likely to continue kissing for long only when they don't feel suffocated. 

While you are at it, take a moment or two to focus on the way she's kissing. Replicate her tongue action and match her tempo. Take the next step only after ensuring you are in the same kissing rhythm and pace as she is. 

CREATIVE TOUCH

Women commonly complain that their man doesn't pull off enough variations while kissing, which they find 'repetitive', 'mechanical', or 'putting off'. So give your girl some variety, like liposuction - moving from the upper lip to the lower, or the earlobe kiss - pressing her earlobe lightly between your lips and tugging gently downward. 

While you are trying to spruce up your smooching repertoire, remember the golden rule: Don't stick your tongue into her mouth, especially not until the situation has sufficiently heated up. 

NECK PECK

This one's a well-established fact - women love to be kissed on the neck. Not only is it their second favourite spot - first being the mouth - it usually turns them on no ends. A clean-shaven man who manages to kiss gently, will vouch for this the most. An elaborate study found that only 10 per cent of men like neck kisses, as opposed to 96 per cent of women. 

MOVE MECHANISM

It's a cliche but that's possibly because it's true. Getting to know one another is the easiest way to iron out the awkwardness and roll out the red carpet for some heady intimacy. Once you know her, wait for the right time and context. This means going for a half-hearted smooch on the sidewalk outside the restaurant may not be a great idea. Take charge of how the atmosphere should be. Dim lights almost always work and so does sharing secrets to ease her into the moment. Take your time, and let her take hers too.

Saturday 7 September 2013

Sugar intake must come down, says WHO

British government's advisory committee, some of whom receive funding from food industry, sceptical about link with obesity by Sarah Boseley

The World Health Organisation is set to recommend a cut in the amount of sugar in our diets in the coming months, following reviews of the scientific evidence of the link with obesity – but any proposed lower limit for sugar will have to overcome scepticism among scientific advisers to the British government.

Next year, the government's scientific advisory committee on nutrition (SACN) will report on carbohydrates, including sugar, in people's diet. Its members, some of whom receive funding from industry, are thought to be sceptical that the sugar is a cause of obesity.

The chairman of the SACN working group on carbohydrates, Professor Ian Macdonald, from Nottingham University, has been on the Mars and Coca-Cola European advisory boards, although he has stepped down from both for the duration of the inquiry.

The professor is the academic lead for his university's "strategic relationship" with Unilever, which owns ice-cream brands as well as margarine and weight-loss products. Unilever's Dr David Mela sits with him on the SACN carbohydrate group and the two are also on the government's calorie reduction expert group, which advises food companies and health groups involved in the Department of Health's Responsibility Deal, aimed at improving public health in England.

Macdonald does not believe his links to Mars and Coca-Cola are a problem. "I have explained my associations with industry to the Department of Health and they are quite happy with the relationships," he said. "I think it's a more balanced view than some of the views of my nutritional colleagues and also than some of the industrial views. Some of the industrial people can't see what they're doing wrong. That's not right – they do need to start helping people to consume sensible amounts of food and be less sedentary than they are at the moment."

However, Macdonald voiced scepticism about some of the claims of the anti-sugar lobby. "But as far as sugar goes, it's difficult to know where to start because there are people who believe it is the cause of all of our problems. [Professor] John Yudkin started this in the 1960s with [his book] Pure, White and Deadly and other people have picked it up at intervals beyond. The consumption rates are a bit higher than they were in the 1960s, but not excessively so. Consumption hasn't trebled."

The belief that the industry should be at the table is common to many of those in the field of nutrition in the UK. The British Nutrition Foundation's director, Professor Judy Buttriss, is also on the calorie reduction group. The foundation takes funding from British Sugar and Tate & Lyle among others, arguing, as some doctors do over drug company funds, that the money has no influence on their scientific independence.

In other quarters concern over sugar in the diet and particularly in sweetened soft drinks has been growing. Health campaigners, worried about rising rates of obesity-related disease such as diabetes and heart problems, have targeted the so-called empty calories in sugar and say that sweetened soft drinks deliver calories without filling people up. The industry says the problem is caused by all of us eating too much of every type of food – not just sugar – and doing too little exercise. It frequently cites studies by industry-funded scientists to make the point.

The WHO's nutrition guidance expert advisory group (NUGAG) is updating its recommendation that sugar should not account for more than 10% of the calories in our diet. That was passed in 2003 only after a fight with the sugar industry. As the Guardian revealed at the time, the US sugar industry threatened to put pressure on the US government to withdraw American funding from the WHO if the restrictions went ahead.
A number of experts think 10% is now too high in the context of rising obesity. The WHO commissioned a review of the scientific evidence on sugar and weight gain to inform NUGAG's discussions from Professor Jim Mann's team at the department of human nutrition and medicine at the University of Otago in New Zealand. It was published in January in the British Medical Journal.

The BMJ paper says that people get fat from eating sugar because they take in too many calories, rather than any intrinsic effect on the metabolism of the sugar itself. But, it says, "when considering the rapid weight gain that occurs after an increased intake of sugars, it seems reasonable to conclude that advice relating to sugars intake is a relevant component of a strategy to reduce the high risk of overweight and obesity in most countries".

Speaking to the Guardian, Mann said that sugar "unquestionably contributes to obesity", although he thinks some anti-sugar campaigners have gone too far. "We've got to try to find the happy medium. I don't think sugar is the cause of all evil. It's an important factor and if we're eating more sugar and less fat then we need to take note of it."

Sugar is energy-dense. People who gave up sugar as part of a trial and were told to consume the same amount of calories from starchy carbohydrates such as bread and potatoes could not do it, Mann said. "They really didn't like it. They felt full. They weren't complaining about anything to do with addiction – they just felt stuffed with food."

Soft drinks containing sugar are not energy-dense in the same way, Mann argues, "but it seems that probably the body doesn't sense calories that come from sugary drinks, so that if one has a Coke with all the vast amount of sugar that it contains you don't register that you've had all these calories".

Sugary drinks, Mann believes, contribute to obesity in younger people, but not in the over-50s, who drink fewer. "But if you look for instance at New Zealand, where I am – Pacific youth for example, who are among the fattest people in the world – sugary drinks probably contribute an enormous amount, as indeed in American youth. How much it contributes to British youth I'm not quite sure but it probably is a significant contributor to youth of all nationalities."

Sugar Nutrition, which used to be called the Sugar Bureau and is funded by the industry, seized on the review's finding that it is the calories consumed that make people fat, rather than something about sugar itself. "Therefore products containing sugars should be consumed within an individual's energy-balanced diet and not in addition, in order to maintain a healthy body weight," it said in a statement.

The UK still officially uses an 11% limit on sugar set 22 years ago by the SACN's predecessor on the basis of tooth damage, although the NHS Choices website refers to 10%. Sugar Nutrition says that "numerous groups" including the European Food Safety Agency and UN Food and Agricultural Organisation have reviewed it since and found no health reason for any limit. "These expert reviews have concluded that the levels of sugars currently consumed are not implicated in any of the lifestyle diseases such as obesity, diabetes, coronary heart disease or cancer," it said.

However, the European Heart Network report in 2011 on diet, physical activity and the prevention of heart disease recommended a sugar limit of less than 10% and set a tentative ambition of reaching 5% in the future.
Mike Rayner, director of the British Heart Foundation health promotion research group at Oxford University and an adviser on the report, believes obesity is caused by too many calories from all kinds of foods. Nevertheless, he is a leading light in the campaign for a soft drinks tax, which would affect consumption.

"The problem with sugar is its calories really and it's easily digestible," he said. "And it tends not to come with anything particularly useful, so sugary drinks are problematic because they are an easy way of getting calories – not because it's sugar but because it's calories. I know there is a difference of opinion. I think nutritionists are rather squabbling over how many angels you get on the side of a pin."

Simon Capewell, professor of clinical epidemiology at Liverpool University, argues there is evidence that taxes on foods with high fat, sugar and fat content will work. But, he says, "industry is doing all it can to stop that happening, including funding scientists. The tactics of the Big Food and Big Soda multinationals are thus very similar to those employed by Big Tobacco. How much longer will society tolerate industry profiting from making children obese?" he asked. "These obese children then face premature deaths, deaths which are 100% preventable."

"Regulation and taxation both work. All we need now is a UK government which is genuinely committed to promoting the public's health, rather than supporting their industry friends' profits."

Smoothies And Fruit Juices Are A New Risk To Health, US Scientists Warn

Scientists say potential damage from naturally occurring fructose in apparently healthy drinks is being overlooked by Sarah Boseley

Fruit juices and smoothies represent a new risk to our health because of the amount of sugar the apparently healthy drinks contain, warn the US scientists who blew the whistle on corn syrup in soft drinks a decade ago.
Barry Popkin and George Bray pointed the finger at high fructose corn syrup in soft drinks in 2004, causing a huge headache for the big manufacturers, including Coca-Cola and Pepsi.

"Smoothies and fruit juice are the new danger," said Popkin, a distinguished professor at the department of nutrition at the University of North Carolina, in an interview with the Guardian. He added: "It's kind of the next step in the evolution of the battle. And it's a really big part of it because in every country they've been replacing soft drinks with fruit juice and smoothies as the new healthy beverage. So you will find that Coke and Pepsi have bought dozens [of fruit juice companies] around the globe."

In the UK, Coca-Cola owns Innocent smoothies while PepsiCo has Tropicana. Launching Tropicana smoothies in 2008, Pepsi's sales pitch was that the drink would help the nation to reach its five a day fruit and vegetable target. "Smoothies are one of the easiest ways to boost daily fruit intake as each 250ml portion contains the equivalent of 2 fruit portions," it said at the time.

However, Popkin says the five a day advice needs to change. Drink vegetable juice, he says, but not fruit juice. "Think of eating one orange or two and getting filled," he said. "Now think of drinking a smoothie with six oranges and two hours later it does not affect how much you eat. The entire literature shows that we feel full from drinking beverages like smoothies but it does not affect our overall food intake, whereas eating an orange does. So pulped-up smoothies do nothing good for us but do give us the same amount of sugar as four to six oranges or a large coke. It is deceiving."

Nine years ago the two scientists had identified sugar-sweetened soft drinks, full of calories and consumed between meals, as a major cause of soaring obesity in developed countries. But they argue that as people change their drinking habits to avoid carbonated soft drinks, the potential damage from naturally occurring fructose in fruit juices and smoothies is being overlooked.

All sugars are equal in their bad effects, says Popkin – even those described on cereal snack bars sold in health food shops as containing "completely natural" sweeteners. "The most important issue about added sugar is that everybody thinks it's cane sugar or maybe beet sugar or HFC syrup or all the other syrups but globally the cheapest thing on the market almost is fruit juice concentrate coming out of China. It has created an overwhelming supply of apple juice concentrate. It is being used everywhere and it also gets around the sugar quotas that lots of countries have."

In a survey of sweeteners in US food products between 2005 and 2009 for a paper published in 2012, Popkin and colleagues found that fruit juice concentrate was the fifth most common sugar overall and the second most common, after corn syrup, in soft drinks and in babies' formula milk.

More studies need to be done before governments and health bodies around the world will take notice. There are only two really good long-term trials – one in Singapore and one by Harvard, he says. "But all the long term studies on fruit juice in anything show the same kind of effect whether it's a smoothie or natural [juice] and whether it's a diabetes or weight gain effect," Popkin added.

Further evidence supporting the theory came last week from a study published by the British Medical Association. Researchers from the UK, USA and Singapore found that, in large-scale studies involving nurses, people who ate whole fruit, especially blueberries, grapes and apples, were less likely to get type 2 diabetes, which is obesity-related, but those who drank fruit juice were at increased risk. People who swapped their fruit juice for whole fruits three times a week cut their risk by 7%.

Most of the attention from those concerned about growing obesity levels among children is still on soft drinks with added sugar, such as colas and lemonade, which are consumed in enormous quantities. In 2012 we drank nearly 227 litres of liquid each in the UK, according to the industry, which says 61% of those had no added sugar. Excluding water brings the "no added sugar" total to 54%. Fruit juices and smoothies are also included in the total. We each drank 17.6 litres of those.

British health campaigners are calling for a soft drinks tax in the UK. In January Sustain published its Children's Future Fund report, saying that £1bn a year could be raised from a tax of 20p a litre and invested in children's health programmes. It has been backed by more than 60 organisations and the first children's commissioner, Al Aynsley-Green, gave his support. In February the Academy of Medical Royal Colleges also called for the tax in its obesity report.

The British Soft Drinks Association says that consumption of soft drinks containing added sugar has fallen by 9% over the last 10 years, while the incidence of obesity has risen by 15%. "Obesity is a serious and complex problem requiring concerted action by a wide range of organisations as well as by people themselves. Soft drinks companies recognize the role they have to play," it said. Companies were reducing the calorie content of their drinks. PepsiCo, it said, had only advertised the no added sugar variants of its soft drinks since 2005.

Innocent Smoothies claims that people who drink juice have better diets and lower rates of obesity than others, although the studies it cited had funding from the juice industry.

"Smoothies are made entirely from fruit and therefore contain the same amount of sugars that you would find in an equivalent amount of whole fruit," it said in a statement.

Meanwhile, efforts by the soft drinks companies to grow the market continue. Coca-Cola in the UK this year declared its ambition to increase the market by £2.1bn by 2017, identifying six "moments" in the day when we could be persuaded to buy more soft drinks, including fruit juice and smoothies for breakfast and soft drinks for children when they come home from school. Sales of sweetened Coca-Cola, containing nine teaspoons of sugar in a standard can, still outstrip those of Diet Coke and Zero Coke combined.

"Unless Coca-Cola drastically reduces its marketing for sugary drinks, its strategy to reach more people more often will mean that it pumps record levels of sugar into our diets," said Charlie Powell, campaigns director of Sustain.

"This is a business model that is unhealthy and unsustainable, perfectly highlighting the 'profit versus public health' conflict of interest endemic in the sugary drinks industry."

Coca-Cola argues that taxes do not change behaviour and that sugar should not be vilified. In a statement, it said: "We believe that rather than single out any ingredient, it is more helpful for people to look at their total energy balance. This is because obesity and weight gain are caused by an imbalance in calories consumed and burnt off. Our products should be enjoyed as part of a sensible, balanced diet and healthy lifestyle that includes regular physical activity. For those that are watching their calorie intake, we offer a wide range of low or no calorie options, which represent more than one third of our sales."

In an article this year in the journal Pediatric Obesity, Bray and Popkin review the issue 10 years on from their famous paper. "The concern with HFCS in our diet has led to a reduced proportion of HFCS in beverages compared to other sugars," they say, but add "this is a misplaced shift … fructose remains a major component of our global diet. To date, to the best of our knowledge every added amount of fructose – be it from fruit juice, sugar-sweetened beverages or any other beverage or even from foods with high sugar content – adds equally to our health concerns linked with this food component."

Monday 2 September 2013

Mumbai Local Trains...

Mumbai Local Trains... written by "Suchitra Rahul Shinde"
SOME INTERESTING FACTS,
if you are a Mumbaikar.... then you will be sure knowing these,

1. Mumbai Local Train where a person think he won battle..... If he gets a window seat in local.

2. You should be the bravest man on earth to catch a Virar train to Borivali during peak hours

3. When we (Mumbaikars) are late for college/ office, Whatever reason maybe, we always blame local trains for delay. 
4. No space Still, people. while boarding the train "arey! khali hai bhai, poora train khali hai" (Hi! It is empty, the whole train is empty)

5. Getting in a empty-ish bogie of a Mumbai train during peak hours and asking, "Yeh First class hai kya?" (Is this First Class Coach)

6. Awesome moment when in local trains you don’t have 2 move towards the exit, you are simply pushed towards it by the crowd!

7. We don't believe that the train is gonna arrive until the time indicator displays "01 mins remaining"

8. When we are in a fully packed train, we always feel like sitting.But, when the train is vacant, we stand at the door!
9. In Mumbai suburb there is a invisible station between Borivali and Kandivali known as “Thambevali”

10. Nobody remains “UNTOUCHED" once u enter Churchgate fast local....

11. Act Dead If Someone asks for your seat in “MUMBAI LOCAL” 
12. No matter how thin or fat are the 3 persons already sitting…someone still occupies the 4th seat in local.......

13. In every local train Journey u will find at least 1 person asking “ arre yeh platform kis taraf aayega??” (On which side the platform will come)

14. “Agla Station Andheri” (Next Station Andheri) puts everyone in the train in ‘Ready to Fight’ mode!

15. If Borivali passenger enters in Virar Train.............then its Inexcusable Crime!!

16. Only Mumbai local travelers know what is “VideoCoach”......means the first class ladies coach attached to gents compartment with a square cut in between..

17. You have the following set of Friends like: School Friends, College friends, Building friends, Office friends and yes, Train friends, a species unique only in Mumbai.
I Love Mumbai ..

Read it, Like it and Share it

“The Best Lines ever said by a Man....."
When I was born, A Woman was there to hold me...... My Mother

As I grew up as a child, A woman was there to care & play with me..... My sister

I went to school, A Woman was there to help me learn...... My Teacher

I needed compatibility, company & Love, A Woman was there for me.. My Wife

I became tough, A Woman was there to melt me..... My Daughter

When I will die, A Woman will be there to absorb me in....... Motherland

If you are a Man, value every Woman...& If you are a Woman, feel proud to be one

!! THE REALITY OF GANDHI !! - Fact or Myth


1. Gandhi used to sleep with girls of ages between 18 to 25. Very few people know about this but its true
(for details you can read books by Dr L .R. BALI named “RANGEELA GANDHI” & “KYA GANDHI MAHATMA THE" {WAS GANDHI A GREAT MAN}) the girls who slept with Gandhi accepted this. Gandhi used to say that he is doing all this for his BRAHMCHARI (Bachelor) Experiments. What from his experiments he wanted to prove nobody knows. Gandhi himself accepted this that at the time of going to London for higher studies he decided to keep himself away from MEAT, ALCOHOL and SEX, but he accepted that he could not control himself in the matter of SEX.



2. Gandhi went to South Africa just to earn money and name because here in India he could not do well, there he went mainly to save Abdullah & Co. whose business was smuggling and charged very much for
this. 


3. In 1932, Gandhi collected 1 Crore & 32 Lakh (200666.40 USD, 151950.93 EUR and 128,436.00 GBP)  in the name of “TILAK SWRAJ” fund, which was collected for the use of DALITS. However, he did not spend a single penny on DALITS.


4. Throughout his entire life Gandhi kept on shouting that, he is in support of AAHIMSA (Non Violence). However, at the time of Second World War he himself sends Indian army for the fight from England's side. AAHIMSA kaha gya uss waqt? (Were was your non violence that time?)



5. During daytime, Gandhi spent the day in the Jhugis but he spent the night in the rest house of Birlas. 


6. Gandhi advised people to live a simple life, but his simplicity was that when he was in jail there were three women in the jail to serve him for his simplicity. 


7. Gandhi did not open a single door of a Hindu temple in Gujrat his home province in India for the UNTOUCHABLES.



8. Gandhi used to say that SUBHASH CHANDRA BOSE is like his own son, but Gandhi went on hunger strike until  Mr. BOSE leaves his post in congress. Gandhi signed a treaty with British govt. that if he found Bose we will handover him to them (Bose was wanted those days).



9. Gandhi kept people in dark by saying that he was trying to save BHAGAT SINGH. However, the truth is that he never tried to contact VICEROY about BHAGAT SINGH issue. This all is said by the friend of VICEROY BHAGAT SINGH named MANMATH NATH in his writings. Gandhi was scared to see the popularity of BHAGAT SINGH because his popularity was increasing of which Gandhi was insecure.



10. Gandhi said that if Pakistan is created, it will only happen after his death. However, it was Gandhi who
signed 1st on the proposal of making Pakistan.


11. Gandhi cheated all Indians at ROUND TABLE CONFERENCES by not giving the details in proper & those details, which were true. 


12. Gandhi started so many ANDOLANS & LEHARS (PROTEST) against British govt. but after a month or so he withdrew all those ANDOLANS & LEHARS. Then what was the use of starting all those? What about the sacrifice of all those people who took part in those ANDOLANS (PROTEST)? In addition, he never went to lead people in those ANDOLANS. Even Gandhi’s own sons were against him but I do not know why people were following him.



13. Now a days almost all Hindu people see him as a revolutionary, but what he said was "I have come
here on earth to fulfill the laws of caste.” How can one say such a person as a revolutionary? A true revolutionary never thinks according to caste line, rich or poor. These are very few points there are many
more truths about Gandhi. In addition, from above point’s you people can decide about Gandhi. In BABA SAHEB’s own words “Gandhi Age is the Dark Age of India”. BABA SAHEB has also said in an interview to BBC that “A PERSON WHO CHEATS AND KEEPS OTHER PEOPLE IN DARK, IF YOU CALL SUCH PERSON A MAHATMA, THEN GANDHI IS A MAHATMA.."

Sunday 1 September 2013

Girls Who Drink Early Increase Risk of Developing Breast Cancer

Women who drink a glass of wine a day during their teens could increase risk of developing breast cancer


Women who drink just one glass of wine a day in their teens and early twenties could be increasing their risk of breast cancer by a third. Scientists have found that consuming fairly small amounts of alcohol early on in life has harmful effects on breast tissue.

Those who drank the equivalent of one glass of wine a day between the age of their first period and when they gave birth to their first child increased their risk by a third. US researchers believe that the breast tissue of young women, which is still developing, is highly susceptible to the harmful effects of alcohol. Although experts have known for some time that alcohol raises the risk of breast cancer, this is one of the first studies to show how it can have an effect so early in life.

Researchers from the Washington University School of Medicine in St Louis examined the drinking habits of 116,671 women aged 25 to 44They were asked to recall how much alcohol they drank a day from the ages of 15 to 17, 18 to 22, and 23 to 30. 

They were also told to note down the age when they first started their periods and when – or if – they gave birth to their first child as pregnancy is known to protect against breast cancer. It was also recorded whether they had ever been diagnosed with the condition.
 

From their answers, the researchers were able to work out roughly how much alcohol the women had drunk per day over the various stages of their lives. The results showed that women who drank a glass of wine a day between their first period and the age at which they had their first child increased their risk of breast cancer by 34 per cent. When alcohol is broken down by the body it creates a substance called acetaldehyde, which can trigger genetic mutations in cells that lead to tumours.

High risk: While still developing, breast tissue of young women is highly susceptible to the harmful effects of alcohol 

It also increases production of oestrogen, the hormone linked to tumour growth. The researchers, whose study is published in the Journal of the National Cancer Institute, said: ‘These findings add support to the importance of exposure [to alcohol] between menarche [the first period] and first pregnancy in breast cancer development.

‘Reducing alcohol consumption during this period may be an effective prevention strategy for breast cancer.’ Richard Francis, head of research at Breakthrough Breast Cancer, said the link was likely to be caused by breast tissue being particularly susceptible to developing cancer between these key ages. ‘We recommend that women of all ages reduce their alcohol intake in order to help prevent breast cancer,’ he said. 

Drinking daily between the age of their first period and when they gave birth to their first child has been found to increase breast cancer risk by a third.

‘Regularly drinking is also associated with a range of other health problems, so we’d urge anyone wanting advice or support on cutting down on alcohol to speak with their doctor.’ Just under 50,000 British women are diagnosed with breast cancer every year and there are around 11,500 deaths annually.

But there is growing evidence that women can drastically lower their risk by adopting healthier lifestyles. Smoking, obesity, a lack of exercise – as well as alcohol – are all thought to trigger the illness. Earlier this year scientists warned that excess drinking was behind soaring rates of breast cancer in the under 50s.

Having Kids at Older Age: - Myth or Fact....

How Older Parenthood Will Upend American Society The scary consequences of the grayest generation. By Juditch Shulevitz

Over the past half century, parenthood has undergone a change so simple yet so profound we are only beginning to grasp the enormity of its implications. It is that we have our children much later than we used to. This has come to seem perfectly unremarkable; indeed, we take note of it only when celebrities push it to extremes—when Tony Randall has his first child at 77; Larry King, his fifth child by his seventh wife at 66; Elizabeth Edwards, her last child at 50. This new gerontological voyeurism—I think of it as doddering-parent porn—was at its maximally gratifying in 2008, when, in almost simultaneous and near-Biblical acts of belated fertility, two 70-year-old women in India gave birth, thanks to donor eggs and disturbingly enthusiastic doctors. One woman’s husband was 72; the other’s was 77.

These, though, are the headlines. The real story is less titillating, but it tells us a great deal more about how we’ll be living in the coming years: what our families and our workforce will look like, how healthy we’ll be, and also—not to be too eugenicist about it—the future well-being of the human race. 

That women become mothers later than they used to will surprise no one. All you have to do is study the faces of the women pushing baby strollers, especially on the streets of coastal cities or their suburban counterparts. American first-time mothers have aged about four years since 1970—as of 2010, they were 25.4 as opposed to 21.5. That average, of course, obscures a lot of regional, ethnic, and educational variation. The average new mother from Massachusetts, for instance, was 28; the Mississippian was 22.9. The Asian American first-time mother was 29.1; the African American 23.1. A college-educated woman had a better than one-in-three chance of having her first child at 30 or older; the odds that a woman with less education would wait that long were no better than one in ten.

It badly misstates the phenomenon to associate it only with women: Fathers have been getting older at the same rate as mothers. First-time fathers have been about three years older than first-time mothers for several decades, and they still are. The average American man is between 27 and 28 when he becomes a father. Meanwhile, as the U.S. birth rate slumps due to the recession, only men and women over 40 have kept having more babies than they did in the past. 

In short, the growth spurt in American parenthood is not among rich septuagenarians or famous political wives approaching or past menopause, but among roughly middle-aged couples with moderate age gaps between them, like my husband and me. OK, I’ll admit it. We’re on the outer edge of the demographic bulge. My husband was in his mid-forties and I was 37—two years past the age when doctors start scribbling AMA, Advanced Maternal Age, on the charts of mothers-to-be—before we called a fertility doctor. The doctor called back and told us to wait a few more months. We waited, then went in. The office occupied a brownstone basement just off the tonier stretches of New York’s Madison Avenue, though its tan, sleek sofas held a large proportion of Orthodox Jewish women likely to have come from another borough. The doctor, oddly, had a collection of brightly colored porcelain dwarves on the shelf behind his desk. I thought he put them there to let you know that he had a sense of humor about the whole fertility racket.

The steps he told us we’d have to take, though, were distinctly unfunny. We’d start with a test to evaluate my fortysomething husband’s sperm. If it passed muster, we’d move on to “injectables,” such as follicle-stimulating and luteinizing hormones. The most popular fertility drug is clomiphene citrate, marketed as Clomid or Serophene, which would encourage my tired ovaries to push those eggs out into the world. (This was a few years back; nowadays, most people take these as pills, which are increasingly common and available, without prescription and possibly in dangerously adulterated form, over the Internet.) I was to shoot Clomid into my thigh five days a month. Had I ever injected anything, such as insulin, into myself? No, I had not. The very idea gave me the willies. I was being pushed into a world I had read about with intense dislike, in which older women endure ever more harrowing procedures in their desperation to cheat time.

If Clomid didn’t work, we’d move into alphabet-soup mode: IVF (in vitro fertilization), ICSI (intracytoplasmic sperm injection), GIFT (gamete intrafallopian transfer), even ZIFT (zygote intrafallopian transfer). All these scary-sounding reproductive technologies involved taking stuff out of my body and putting it back in. Did these procedures, or the hormones that came with them, pose risks to me or to my fetus? The doctor shrugged. There are always risks, he said, especially when you’re older, but no one is quite sure whether they come from advanced maternal age itself or from the procedures.

My husband passed his test. I started on my routines. With the help of a minor, non–IVF-related surgical intervention and Clomid, which had the mild side effects of making me feel jellyfish-like and blurring my already myopic vision, I got pregnant.

My baby boy seemed perfect. When he was three, though, the pediatrician told me that he had a fine-motor delay; I was skeptical, but after a while began to notice him struggling to grasp pencils and tie his shoes. An investigator from the local board of education confirmed that my son needed occupational therapy. This, I discovered, was another little culture, with its own mystifying vocabulary. My son was diagnosed with a mild case of “sensory-integration disorder,” a condition with symptoms that overlapped with less medical terms like “excitable” and “sensitive.”

Sitting on child-sized chairs outside the little gyms in which he exercised an upper body deemed to have poor muscle tone, I realized that here was a subculture of a subculture: that of mothers who spend hours a week getting services for developmentally challenged children. It seemed to me that an unusually large proportion of these women were older, although I didn’t know whether to make anything of that or dismiss it as the effect of living just outside a city—New York—where many women establish themselves in their professions before they have children.

I also spent those 50-minute sessions wondering: What if my son’s individual experience, meaningless from a statistical point of view, hinted at a collective problem? As my children grew and, happily, thrived (I managed to have my daughter by natural means), I kept meeting children of friends and acquaintances, all roughly my age, who had Asperger’s, autism, obsessive-compulsive disorder, attention-deficit disorder, sensory-integration disorder. Curious as to whether there were more developmental disabilities than there used to be, I looked it up and found that, according to the Centers for Disease Control, learning problems, attention-deficit disorders, autism and related disorders, and developmental delays increased about 17 percent between 1997 and 2008. One in six American children was reported as having a developmental disability between 2006 and 2008. That’s about 1.8 million more children than a decade earlier.

Soon, I learned that medical researchers, sociologists, and demographers were more worried about the proliferation of older parents than my friends and I were. They talked to me at length about a vicious cycle of declining fertility, especially in the industrialized world, and also about the damage caused by assisted-reproductive technologies (ART) that are commonly used on people past their peak childbearing years. This past May, an article in the New England Journal of Medicine found that 8.3 percent of children born with the help of ART had defects, whereas, of those born without it, only 5.8 percent had defects.

A phrase I heard repeatedly during these conversations was “natural experiment.” As in, we’re conducting a vast empirical study upon an unthinkably large population: all the babies conceived by older parents, plus those parents, plus their grandparents, who after all have to wait a lot longer than they used to for grandchildren. It was impressed upon me that parents like us, with our aging reproductive systems and avid consumption of fertility treatments, would change the nature of family life. We might even change the course of our evolutionary future. For we are bringing fewer children into the world and producing a generation that will be subtly different—“phenotypically and biochemically different,” as one study I read put it—from previous generations.

What science tells us about the aging parental body should alarm us more than it does. Age diminishes a woman’s fertility; every woman knows that, although several surveys have shown that women—and men—consistently underestimate how sharp the drop-off can be for women after age 35. The effects of maternal age on children aren’t as well-understood. As that age creeps upward, so do the chances that children will carry a chromosomal abnormality, such as a trisomy. In a trisomy, a third chromosome inserts itself into one of the 23 pairs that most of us carry, so that a child’s cells carry 47 instead of 46 chromosomes. The most notorious trisomy is Down syndrome. There are two other common ones: Patau syndrome, which gives children cleft palates, mental retardation, and an 80 percent likelihood of dying in their first year; and Edwards syndrome, which features oddly shaped heads, clenched hands, and slow growth. Half of all Edwards syndrome babies die in the first week of life.

The risk that a pregnancy will yield a trisomy rises from 2–3 percent when a woman is in her twenties to 30 percent when a woman is in her forties. A fetus faces other obstacles on the way to health and well-being when born to an older mother: spontaneous abortion, premature birth, being a twin or triplet, cerebral palsy, and low birth weight. (This last leads to chronic health problems later in children’s lives.)

We have been conditioned to think of reproductive age as a female-only concern, but it isn’t. For decades, neonatologists have known about birth defects linked to older fathers: dwarfism, Apert syndrome (a bone disorder that may result in an elongated head), Marfan syndrome (a disorder of the connective tissue that results in weirdly tall, skinny bodies), and cleft palates. But the associations between parental age and birth defects were largely speculative until this year, when researchers in Iceland, using radically more powerful ways of looking at genomes, established that men pass on more de novo—that is, non-inherited and spontaneously occurring—genetic mutations to their children as they get older. In the scientists’ study, published in Nature, they concluded that the number of genetic mutations that can be acquired from a father increases by two every year of his life, and doubles every 16, so that a 36-year-old man is twice as likely as a 20-year-old to bequeath de novo mutations to his children.

The Nature study ended by saying that the greater number of older dads could help to explain the 78 percent rise in autism cases over the past decade. Researchers have suspected links between autism and parental age for years. One much-cited study from 2006 argued that the risk of bearing an autistic child jumps from six in 10,000 before a man reaches 30 to 32 in 10,000 when he’s 40—a more than fivefold increase. When he reaches 50, it goes up to 52 in 10,000. It should be noted that there are many skeptics when it comes to explaining the increase of autism; one school of thought holds that it’s the result of more doctors making diagnoses, better equipment and information for the doctors to make them with, and a vocal parent lobby that encourages them. But it increasingly looks as if autism cases have risen more than overdiagnosis can account for and that parental age, particularly paternal age, has something to do with that fact.

Why do older men make such unreliable sperm? Well, for one thing, unlike women, who are born with all their eggs, men start making sperm at puberty and keep doing so all their lives. Each time a gonad cell divides to make spermatozoa, that’s another chance for its DNA to make a copy error. The gonads of a man who is 40 will have divided 610 times; at 50, that number goes up to 840. For another thing, as a man ages, his DNA’s self-repair mechanisms work less well.

To the danger of age-related genetic mutations, geneticists are starting to add the danger of age-related epigenetic mutations—that is, changes in the way genes in sperm express themselves. Epigenetics, a newish branch of genetics, studies how molecules latch onto genes or unhitch from them, directing many of the body’s crucial activities. The single most important process orchestrated by epigenetic notations is the stupendously complex unfurling of the fetus. This extra-genetic music is written, in part, by life itself. Epigenetically influenced traits, such as mental functioning and body size, are affected by the food we eat, the cigarettes we smoke, the toxins we ingest—and, of course, our age. Sociologists have devoted many man-hours to demonstrating that older parents are richer, smarter, and more loving, on the whole, than younger ones. And yet the tragic irony of epigenetics is that the same wised-up, more mature parents have had longer to absorb air-borne pollution, endocrine disruptors, pesticides, and herbicides. They may have endured more stress, be it from poverty or overwork or lack of social status. All those assaults on the cells that make sperm DNA can add epimutations to regular mutations.

At the center of research on older fathers, genetics, and neurological dysfunctions is Avi Reichenberg, a tall, wiry psychiatrist from King’s College in London. He jumps up a lot as he talks, and he has an ironic awareness of how nervous his work makes people, especially men. He can identify: He had his children relatively late—mid-thirties—and fretted throughout his wife’s pregnancies. Besides, he tells me, the fungibility of sperm is just plain disturbing. Reichenberg likes to tell people about all the different ways that environmental influences alter epigenetic patterns on sperm DNA. That old wives’ tale about hot baths or tight underwear leading to male infertility? It’s true. “Usually when you give that talk, men sitting like that”—he crossed his legs—“go like this,” he said, opening them back up.

Dolores Malaspina, a short, elegantly coiffed psychiatrist who speaks in long, urgent paragraphs, has also spent her life worrying people about aging men’s effects on their children’s mental state—in fact, she could be said to be the dean of older-father alarmism. In 2001, Malaspina co-authored a ground-breaking study that concluded that men over 50 were three times more likely than men under 25 to father a schizophrenic child. Malaspina and her team derived that figure from a satisfyingly large population sample: 87,907 children born in Jerusalem between 1964 and 1976. (Luckily, the Israeli Ministry of Health recorded the ages of their fathers.) Malaspina argued that the odds of bearing a schizophrenic child moved up in a straight line as a man got older. Other researchers dismissed her findings, arguing that men who waited so long to have children were much more likely to be somewhat schizophrenic themselves. But Malaspina’s conclusions have held up. A 2003 Danish study of 7,704 schizophrenics came up with results similar to Malaspina’s, although it concluded that a man’s chances of having a schizophrenic child jumped sharply at 55, rather than trending steadily upward after 35.

“I often hear from teachers that the children of much older fathers seem more likely to have learning or social issues,” she told me. Now, she said, she’d proved that they can be. Showing that aging men have as much to worry about as aging women, she told me, is a blow for equality between the sexes. “It’s a paradigm shift,” she said.

This paradigm shift may do more than just tip the balance of concern away from older mothers toward older fathers; it may also transform our definition of mental illness itself. “It’s been my hypothesis, though it is only a hypothesis at this point, that most of the disorders that afflict neuropsychiatric patients—depression, schizophrenia, and autism, at least the more extreme cases—have their basis in the early processes of brain maturation,” Dr. Jay Gingrich, a professor of psychobiology at the New York State Psychiatric Institute and a former colleague of Malaspina’s, told me. Recent mouse studies have uncovered actual architectural differences between the brains of offspring of older fathers and those of younger fathers. Gingrich and his team looked at the epigenetic markings on the genes in those older-fathered and younger-fathered brains and found disparities between them, too. “So then we said: ‘Wow, that’s amazing. Let’s double down and see whether we can see differences in the sperm DNA of the older and younger fathers,’” Gingrich said. And they didn’t just see it, he continued; they saw it “in spades—with an order of magnitude more prominent in sperm than in the brain.” While more research needs to be done on how older sperm may translate into mental illness, Gingrich is confident that the link exists. “It’s a fascinating smoking gun,” he says.

Epigenetics is also forcing medical researchers to reopen questions about fertility treatments that had been written off as answered and done with. Fertility doctors do a lot of things to sperm and eggs that have not been rigorously tested, including keeping them in liquids (“culture media,” they’re called) teeming with chemicals that may or may not scramble an embryo’s development—no one knows for sure. There just isn’t a lot of data to work with: The fertility industry, which is notoriously under-regulated, does not give the government reports on what happens to the children it produces. As Wendy Chavkin, a professor of obstetrics and population studies at Columbia University’s school of public health, says, “We keep pulling off these technological marvels without the sober tracking of data you’d want to see before these things become widespread all over the world.”

Clomid, or clomiphene citrate, which has become almost as common as aspirin in women undergoing fertility treatments, came out particularly badly in the recent New England Journal of Medicine study that rang alarm bells about ART and birth defects. “I think it’s an absolute time bomb,” Michael Davies, the study’s lead researcher and a professor of pediatrics at the University of Adelaide in Australia, told me. “We estimate that there may be in excess of 500 preventable major birth defects occurring annually across Australia as a direct result of this drug,” he wrote in a fact sheet he sent me. Dr. Jennita Reefhuis, an epidemiologist at the Centers for Disease Control, worries that Clomid might build up in women’s bodies when they take it repeatedly, rather than washing out of the body as it is supposed to. If so, the hormonal changes induced by the drug may misdirect early fetal development.

Another popular procedure coming under renewed scrutiny is ICSI (intracytoplasmic sperm injection). In ICSI, sperm or a part of a sperm is injected directly into an extracted egg. In the early ’90s, when doctors first started using ICSI, they added it to in vitro fertilization only when men had low sperm counts, but today doctors perform ICSI almost routinely—procedures more than doubled between 1999 and 2008. And yet, ICSI shows up in the studies as having higher rates of birth defects than any other popular fertility procedure. Among other possible reasons, ICSI allows sperm to bypass a crucial step in the fertilization of the egg—the binding of the head of the sperm with the coat of the egg. Forcing the sperm to penetrate the coat may be nature’s way of maintaining quality control.

A remarkable feature of the new older parenting is how happy women seem to be about it. It’s considered a feminist triumph, in part because it’s the product of feminist breakthroughs: birth control, which gives women the power to pace their own fertility, and access to good jobs, which gives them reason to delay it. Women simply assume that having a serious career means having children later and that failing to follow that schedule condemns them to a lifetime of reduced opportunity—and they’re not wrong about that. So each time an age limit is breached or a new ART procedure is announced, it’s met with celebration. Once again, technology has given us the chance to lead our lives in the proper sequence: education, then work, then financial stability, then children.

As a result, the twenties have turned into a lull in the life cycle, when many young men and women educate themselves and embark on careers or journeys of self-discovery, or whatever it is one does when not surrounded by diapers and toys. This is by no means a bad thing, for children or for adults. Study after study has shown that the children of older parents grow up in wealthier households, lead more stable lives, and do better in school. After all, their parents are grown-ups.

But the experience of being an older parent also has its emotional disadvantages. For one thing, as soon as we procrastinators manage to have kids, we also become members of the “sandwich generation.” That is, we’re caught between our toddlers tugging on one hand and our parents talking on the phone in the other, giving us the latest updates on their ailments. Grandparents well into their senescence provide less of the support younger grandparents offer—the babysitting, the spoiling, the special bonds between children and their elders through which family traditions are passed.

Another downside of bearing children late is that parents may not have all the children they dreamed of having, which can cause considerable pain. Long-term studies have shown that, when people put off having children till their mid-thirties and later, they fail to reach “intended family size”—that is, they produce fewer children than they’d said they’d meant to when interviewed a decade or so earlier. A matter of lesser irritation (but still some annoyance) is the way strangers and even our children’s friends confuse us with our own parents. My husband has twice been mistaken for our daughter’s grandfather; he laughs it off, but when the same thing happened to a woman I know, she was stung.

What haunts me about my children, though, is not the embarrassment they feel when their friends study my wrinkles or my husband’s salt-and-pepper temples. It’s the actuarial risk I run of dying before they’re ready to face the world. At an American Society for Reproductive Medicine meeting last year, two psychologists and a gynecologist antagonized a room full of fertility experts by making the unpopular but fairly obvious point that older parents die earlier in their children’s lives. (“We got a lot of blowback in terms of reproductive rights and all that,” the gynecologist told me.) A mother who is 35 when her child is born is more likely than not to have died by the time that child is 46. The one who is 45 may have bowed out of her child’s life when he’s 37. The odds are slightly worse for fathers: The 35-year-old new father can hope to live to see his child turn 42. The 45-year-old one has until the child is 33.

These numbers may sound humdrum, but even under the best scenarios, the death of a parent who had children late, not to mention the long period of decline that precedes it, will befall those daughters and sons when they still need their parents’ help—because, let’s face it, even grown-up children rely on their parents more than they used to. They need them for guidance at the start of their careers, and they could probably also use some extra cash for the rent or the cable bill, if their parents can swing it. “If you don’t have children till your forties, they won’t be launched until you’re in your sixties,” Suzanne Bianchi, a sociologist who studies families, pointed out to me. In today’s bad economy, young people need education, then, if they can afford it, more education, and even internships. They may not go off the parental payroll until their mid- to late-twenties. Children also need their parents not to need them just when they’ve had children of their own.

There’s an entire body of sociological literature on how parents’ deaths affect children, and it suggests that losing a parent distresses young adults more than older adults, low-income young adults more than high-income ones, and daughters more than sons. Curiously, the early death of a mother correlates to a decline in physical health in both sexes, and the early death of a father correlates to increased drinking among young men, perhaps because more men than women have drinking problems and their sons are more likely to copy them.

All these problems will be exacerbated if we aging parents are, in fact, producing a growing subpopulation of children with neurological or other disorders who will require a lifetime of care. Schizophrenia, for instance, usually sets in during a child’s late teens or early twenties. Avi Reichenberg sums up the problem bluntly. “Who is going to take care of that child?” he asked me. “Some seventy-five-year-old demented father?”

This question preys on the mind of every parent whose child suffers a disability, whether that parent is elderly or not. The best answer to it that I’ve ever heard came from a 43-year-old father I met named Patrick Spillman, whose first child, Grace, a four-and-a-half-year-old, has a mild case of cerebral palsy. (Her mother was 46 when Grace was born.) In his last job, Spillman, stocky and blunt, directed FreshDirect’s coffee department. Now, he’s a full-time father and advocate for his daughter. He spends his days taking Grace to doctors and therapists and orthotic-boot-makers, as well as making won’t-take-no-for-an-answer phone calls to state and city agencies that might provide financial or therapeutic assistance. How does he face the prospect of disappearing from her life? A whole lot better than I would. (My lame-joke answer, when my children ask me that question, is that I plan to live forever.) “We’re putting money aside now,” he said. Into a trust, he adds, so that government agencies can’t count it against her when she or a caregiver goes looking for Medicaid or other benefits.

Spillman also prepares Grace for the future by practicing tough love on her, refusing to do for her anything she could possibly do for herself. Her mother, he says, sometimes pleads with him to help Grace more as she stumbles over the tasks of daily life. But he won’t. At her tender age, Grace already dresses and undresses herself; every morning, Spillman explained, they do a little “tag check dance” to make sure nothing’s inside out. When, he says, someone makes fun of her way of walking and chewing and speaking, as he believes someone will inevitably do, “I want her to have years and years of confidence behind her.” He adds, “She’s going to go to college. She will be well-adjusted. She won’t be able to live on a nineteenth-floor walk-up, but she will live a normal life.”

When we look back at this era from some point in the future, I believe we’ll identify the worldwide fertility plunge as the most important legacy of old-age parenting. A half-century ago, demographers were issuing neo-Malthusian manifestoes about the overpeopling of the Earth. Nowadays, they talk about the disappearance of the young. Fertility has fallen below replacement rates in the majority of the 224 countries—developing as well as developed—from which the United Nations collects such information, which means that more people die in those places than are born. Baby-making has slumped by an astonishing 45 percent around the world since 1975. By 2010, the average number of births per woman had dropped from 4.7 to 2.6. No trend that large has a simple explanation, but the biggest factor, according to population experts, is the rising age of parents—mothers, really—at the birth of their first children. That number, above all others, predicts how large a family will ultimately be.

Fewer people, of course, means less demand for food, land, energy, and all the Earth’s other limited resources. But the environmental benefits have to be balanced against the social costs. Countries that can’t replenish their own numbers won’t have younger workers to replace those who retire. Older workers will have to be retrained to cope with the new technologies that have transmogrified the workplace. Retraining the old is more expensive than allowing them to retire to make way for workers comfortable with computers, social media, and cutting-edge modes of production. And who will take care of the older generations if there aren’t enough in the younger ones?

If you’re a doctor, you see clearly what is to be done, and you’re sure it will be. “People are going to change their reproductive habits,” said Alan S. Brown, a professor of psychiatry and epidemiology at the Columbia University medical school and the editor of an important anthology on the origins of schizophrenia. They will simply have to “procreate earlier,” he replied. As for men worried about the effects of age on children, they will “bank sperm and freeze it.”

Would-be mothers have been freezing their eggs since the mid-’80s. Potential fathers don’t seem likely to rush out to bank their sperm any time soon, though. Dr. Bruce Gilbert, a urologist and fertility specialist who runs a private sperm bank on Long Island, told me he has heard of few men doing so, if any. Doctors have a hard enough time convincing men to store their sperm when they’re facing cancer treatments that may poison their gonads, Gilbert said. The only time he saw an influx of men coming in to store sperm was during the first Gulf war, when soldiers were being shipped out to battlefields awash in toxic agents. Moreover, sperm banking is too expensive to undertake lightly, up to $850 for processing, then $300 to $500 a year for storage. “There needs to be a lot more at stake than concern about aging and potential for genetic alterations,” Gilbert said. “It has to be something more immediate.”

What else can be done? Partly the same old things that are already being done, though perhaps not passionately enough. Doctors will have to get out the word about how much male and female fertility wanes after 35; make it clear that fertility treatments work less well with age; warn that tinkering with reproductive material at the very earliest stages of a fetus’s growth may have molecular effects we’re only beginning to understand.

But I’m not convinced that medical advice alone will lead people to “procreate earlier.” You don’t buck decades-old, worldwide trends that easily. The problem seems particularly hard to solve in the United States, where it’s difficult to imagine legislators adopting the kinds of policies it will take to stop the fertility collapse.

Demographers and sociologists agree about what those policies are. The main obstacle to be overcome is the unequal division of the opportunity cost of babies. When women enjoy the same access to education and professional advancement as men but face penalties for reproducing, then, unsurprisingly, they don’t. Some experts hold that, to make up for mothers’ lost incomes, we should simply hand over cash for children: direct and indirect subsidies, tax exemptions, mortgage-forgiveness programs. Cash-for-babies programs have been tried all over the world—Hungary and Russia, among other places—with mixed results; the subsidies seem to do little in the short term, but may stem the ebbing tide somewhat over the long term. One optimistic study done in 2003 of 18 European countries that had been giving families economic benefits long enough for them to kick in found a 25 percent increase in women’s fertility for every 10 percent increase in child benefits.

More immediately effective are policies in place in many countries in Western Europe (France, Italy, Sweden) that help women and men juggle work and child rearing. These include subsidized child care, generous parental leaves, and laws that guarantee parents’ jobs when they go back to work. Programs that let parents stay in the workforce instead of dropping out allow them to earn more over the course of their lifetimes.

Sweden and France, the two showcases for such egalitarian family policies, have among the highest rates of fertility in the Western half of Europe. Sweden, however, ties its generous paid parental leaves to how much a parent has been making and how long she has been working, which largely leaves out all the people in their twenties who aren't working yet because they’re still in school or a training program. In other words, even a country with one of the most liberal family policies in the world gives steeply reduced benefits to its most ambitious and promising citizens at the very moment when they should be starting their families.

It won’t be easy to make the world more baby-friendly, but if we were to try, we’d have to restructure the professions so that the most intensely competitive stage of a career doesn't occur right at the moment when couples should be lavishing attention on infants. We’d have to stop thinking of work-life balance as a women’s problem, and reframe it as a basic human right. Changes like these are going to be a long time coming, but I can’t help hoping they happen before my children confront the Hobson’s choices that made me wait so long to have them.